Table 1.
Published Reports on EFTR with FTRD in Humans. Technical Success is Defined as Successful Deployment of the OTSC on the Target Lesion While Clinical Success as R0 Resection at Histopathological Analysis
| Study | Type of resection | Indication for FTRD (n) | Patients (n) | Mean age (yr) | Lesion location (n) | Mean lesion size (mm) (range) | Final histopathologic diagnosis (n) | Technical success (%) | Clinical success (%) | AEs |
|---|---|---|---|---|---|---|---|---|---|---|
| Fähndrich et al. (2015) [5] | FTRD | Reresection after R1 resection (1) | 1 | 74.0 | AC (1) | 25.0 | Not specified (1) | 100 | 100 | 0 |
| Valli et al. (2014) [12] | FTRD | Adenoma (1) | 1 | 66.0 | Diverticulum of AC (1) | 13.0 | Adenoma with LGD (1) | 100 | 100 | 0 |
| Schmidt et al. (2015) [10] | FTRD | Nonlifting adenoma (13), other adenoma (7), re-resection after T1 carcinoma (2), submucosal tumor (2), suspicion of HD (1) | 25a) | 70.0 | Cecum (5), AC (5), TC (3), DC (4), sigmoid (2), RST (3), rectum (2) | 24.0 (12–40) | Adenoma with LGD (10), adenoma with HGD (10), normal tissue (3), leiomyoma (1), hamartoma (1) | 83.3 | 75 | 1° |
| Schmidt et al. (2015) [9] | FTRD | Submucosal tumor (1), nonlifting adenoma (1), NET (1), | 4 | 60.7 | Duodenum (4) | 28.3 (22–40) | Adenoma with HGD (2), NET (1), inflammatory fibroid polyp (1) | 100 | 75 | 2° |
| Klare et al. (2015) [13] | FTRD | Re-resection after NET (1) | 1 | 50.0 | Rectum (1) | 10.0 | Normal tissue (1) | 100 | 100 | 0 |
| Richter-Schrag et al. (2016) [8] | FTRD | Non lifting adenoma (3), T1 carcinoma (6), NET (2), re-resection after adenoma (9) | 20 | 60.5 | Rectum (11), Colon (9) | 24.8 (16–54) | Fibrose (8), adenocarcinoma (2), adenoma with LGD (4), adenoma with HGD (2), ulcer (1), normal tissue (1), not specified (1) | 75.0 | 80 | 2° |
EFTR, endoscopic full-thickness resection; FTRD, full-thickness resection device; OTSC, over-the-scope-clip; AEs, adverse events; AC, ascending colon; LGD, low grade dysplasia; HD, Hirschsprung’s disease; TC, transverse colon; DC, descendig colon; RST, rectosigmoid transition; HGD, high grade dysplasia; NET, neuroendocrine tumor.
a)
In one case target lesion could not be reached;
°
Bleeding.