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. 2016 Sep 27;4(4):32. doi: 10.3390/dj4040032

Table 1.

Included studies.

Year Author Study Design Disease Patients (n) ONJ Cases Prevalence (%) Used Agent
2005 Bamias [17] pros breast ca 70 2 2.86 Z, PZ, ZI
pros mult myel 111 11 9.91 Z, PZ, ZI
pros prostate ca 46 3 6.52 Z, PZ, ZI
Durie [18] web survey mult myel 904 62 6.86 Z, P
web survey breast ca 299 13 4.35
Guarneri [19] retro breast ca 48 3 6.25 P
2006 Badros [20] retro mult myel 340 11 3.24 P, Z, PZ
Calvo-Villas [21] retro mult myel 64 7 10.94 Z
Dimopoulos [22] pros mult myel 202 15 7.43 Z
Sanna [23] pros breast ca 81 5 6.17 P, Z
Tosi [24] retro mult myel 259 9 3.47 Z
Zervas [25] pros mult myel 254 28 11.02 Z, P, ZP
Ortega [26] ? breast ca 126 2 1.59 Z
2007 Aguiar Bujanda [27] css breast ca 35 4 11.43 Z
Corso [28] retro mult myel 106 8 7.55 Z, PZ
García Sáenz [29] pros prostate ca 104 3 2.88 Z
Jadu [30] retro mult myel 655 21 3.21 P
Ortega [31] retro prostate ca 52 6 11.54 Z
Petrucci [32] ? mult myel 311 22 7.07 Z, P, PZ
Wang [33] retro mult myel 292 11 3.77 Z, P, Z
retro breast ca 81 2 2.47 Z, P, Z
retro prostate ca 69 2 2.9 Z, P, Z
Lipton [34] prosp breast ca 211 0 0 D
Pozzi [35] retro mult myel 1402 28 2 Z, PZ
2008 Boonyapakorn [36] pros mult myel 58 10 17.24 P, PZ, IZ, Z
Fehm [37] retro breast ca 233 10 4.29 Z, ICPZ
Ibrahim [38] retro breast ca 220 5 2.27 PZ, Z
retro mult myel 59 2 3.39 PZ, Z
Walter [39] css prostate ca 43 8 18.6 IZ, PZ, Z
Yonemori [40] prosp breast ca 18 0 0 D
Ellis [41] prosp breast ca 106 0 0 D
Christodoulou [42] retro breast ca 75 2 2.67 Z, I
retro prostate ca 11 1 9.1 Z, I
Estilo [43] retro breast ca 134 18 13.43 P, Z, PZ
retro prostate ca 31 4 12.9 P, Z, PZ
retro mult myel 145 6 4.14 P, Z, PZ
Hoff [14] retro breast ca 1338 16 1.2 P, Z
retro mult myel 548 13 2..37 P, Z
Montefusco [44] retro mult myel 178 9 5.06 BP
Musto [45] prosp mult myel 81 1 1.23 Z
2009 Walter [46] css breast ca 75 4 5.33 Z, PZI
Aragon-Ching [47] pros prostate ca 60 11 18.33 Z
Cetiner [48] pros mult myel 32 5 15.63 Z
Crawford [49] retro breast ca 113 10 3.5 P, PZ, Z
Dimopoulos [50] pros mult myel 128 16 12.5 Z
Haidar [51] retro prostate ca 51 2 3.92 Z
Ripamonti [52] retro breast ca 590 18 3.05 P, PZ, Z
prosp breast ca 112 2 1.79 P, PZ, Z
Vahtsevanos [53] retro breast ca 1041 32 3.07 Z, P, I, PZ, IZ
retro mult myel 539 46 8.53 P, PZ, Z
retro prostate ca 41 2 4.88 P, Z, ZI
Fizazi [54] prosp prostate 17 0 0 P, Z
prosp breast ca 16 0 0 P, Z
prosp prostate ca 33 0 0 D
prosp breast ca 30 0 0 D
Bonomi [55] retro breast ca 238 7 2.94 P, PZ, Z
retro protate ca 46 1 2.17 P, PZ, Z
Stumpe [56] retro mult myel 128 3 2.34 P, Z, PZ
retro breast ca 241 1 0.41 P, Z, PZ
retro prostate ca 128 1 0.78 P, Z, PZ
2010 Walter [16] retro mult myel 81 4 4.94 U, PZ
css mult myel 78 16 20.51 Z, PZ, IZ, PZI
Bantis [11] retro prostate ca 60 9 15 Z
Gimsing [57] retro breast ca 250 8 3.2 P normal dose (90 mg)
retro breast ca 252 2 0.79 P low dose (30 mg)
Pakovic [58] retro mult myel 190 2 1.05 P, PI, I
Stopeck [59] prosp breast ca 1020 20 1.96 D
prosp breast ca 1013 14 1.38 Z
2011 Fizazi [60] prosp prostate ca 950 22 2.32 D
prosp prostate ca 951 12 1.26 Z
Quispe [61] retro breast ca 110 10 9.09 Z
2012 Ding [62] retro breast ca 181 1 0.55 P, I, Z
Miyazaki [63] retro prostate ca 111 9 8.11 Z
Smith [64] prosp prostate ca 716 33 4.61 D
Thumbigere-Math [65] retro breast ca 190 8 4.21 P, PZ, Z
retro mult myel 83 6 7.23 P, PZ, Z
retro prostate ca 84 2 2.38 P, PZ, Z
Rugani [66] retro breast ca 48 5 10.42 Z
Then [67] retro mult myel 120 23 19.17 P, Z, I
Martin [68] prosp breast ca 1026 0 0 D
Henry [69] + Saad [70] prosp mult myel 180 6 3.33 D,Z
2013 Assaf [71] retro breast ca 95 9 9.47 P, I, Z, ZI, PI
retro mult myel 42 5 11.9 P, I, Z, ZI, PI
Coleman [72] prosp breast ca 1065 5 0.47 Z
Brufsky [73] retro breast ca 159 6 3.77 P, Z, PZ
retro breast ca 62 1 1.61 P, Z, PZ
Rathbone [74] prosp breast ca 1681 26 1.55 Z
2014 Barrett-Lee [75] prosp breast ca 697 9 1.29 Z
Coleman [76] prosp breast ca 1685 26 1.54 Z
Jackson [77] prosp mult myel 981 36 3.67 Z
Gnant [78] prosp breast ca 900 0 0 Z
2015 Vidal-Real [79] retro prostate ca 43 9 20.93 Z
retro breast ca 15 4 26.67 Z
retro mult myel 18 0 0 Z
Rodrigues [80] prosp prostate ca 324 2 0.62 Z
2016 Stopeck [81] prosp breast ca 318 20 6.29 D
prosp breast ca 334 18 5.39 ZD
prosp prostate ca 147 12 8.16 D
prosp prostate ca 118 7 5.93 ZD

Abbreviations: prosp (prospective), retro (retrospective), ccs (cross-sectional study), ? (unknown), ca (cancer), mult myel (multiple myeloma), Z (zoldronate), P (pamidonate), I (ibandronate), D (denosumab).