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Schematic presentation of MSCs giving rise to adipocyte differentiation.
MSCs can differentiate into adipocytes when placed in the adipogenesis medium in vitro. Various adipokines including Ang II, Leptin, TGFβ, VEGF, FGF, HGF, TNF, Adiponectin, MMP-2, MMP-9 and IGF-1 are secreted from adipocytes. Particular molecular events accompanying each stage of differentiation are indicated to the right, with the imprecise interval in each stage reflected as indicated.
