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. 2018 Jan 4;52(3):787–803. doi: 10.3892/ijo.2018.4236

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Copyright: © Zaatiti et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The transcriptional knockdown of tumorigenic proteins significantly decreases protein expression. (A) Transient transfection with siRNA targeting L1-cell adhesion molecule (L1-CAM), high mobility group protein A1 (HMGA1), MYCN proto-oncogene, bHLH transcription factor (MYCN) and fatty-acid binding protein 5 (FABP5) abrogated their protein expression. (B) Densitometric analysis of multiple experimental repeats revealed a significant decrease in the expression of the said proteins compared to control siRNA-transfected cells. Experiments were run in triplicate and repeated >3 times. Results represent the means ± SEM; ^*P<0.05 and ^**P<0.001.