Table VI.
Common tumorigenic pathways that MYC and our validated targets (BIRC5, HMGA1 and MYCN) mapped to.
| Pathway ID no. | Pathway description | Observed gene count | False discovery rate | Matching proteins in your network (labels) |
|---|---|---|---|---|
| GO.0051301 | Cell division | 6 | 0.000118 | AURKA, AURKB, BIRC5, CDCA8, CDK1, INCENP |
| GO.0007067 | Mitotic nuclear division | 5 | 0.000834 | AURKB, BIRC5, CDCA8, CDK1, INCENP |
| GO.0007052 | Mitotic spindle organization | 3 | 0.0017 | AURKA, AURKB, BIRC5 |
| GO.0007059 | Chromosome segregation | 4 | 0.0017 | AURKB, BIRC5, CDCA8, INCENP |
| GO.0043146 | Spindle stabilization | 2 | 0.00178 | AURKA, AURKB |
| GO.0051225 | Spindle assembly | 3 | 0.00178 | AURKA, AURKB, BIRC5 |
| GO.0051302 | Regulation of cell division | 4 | 0.00382 | AURKA, AURKB, BIRC5, MYC |
| GO.0007264 | Small GTPase-mediated signal transduction | 5 | 0.00405 | AURKB, BIRC5, CDCA8, CDK1, INCENP |
| GO.0000910 | Cytokinesis | 3 | 0.00568 | AURKB, BIRC5, INCENP |
| GO.0031145 | Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 3 | 0.00568 | AURKA, AURKB, CDK1 |
| GO.0010941 | Regulation of cell death | 6 | 0.00604 | AURKA, AURKB, BIRC5, CDK1, MYC, MYCN |
| GO.0006468 | Protein phosphorylation | 5 | 0.00685 | AURKA, AURKB, BIRC5, CDK1, MYC |
| GO.0018105 | Peptidyl-serine phosphorylation | 3 | 0.00685 | AURKA, AURKB, CDK1 |
| GO.0034501 | Protein localization to kinetochore | 2 | 0.00685 | AURKB, CDK1 |
| GO.0035404 | Histone-serine phosphorylation | 2 | 0.00685 | AURKA, AURKB |
| GO.0043066 | Negative regulation of apoptotic process | 5 | 0.00685 | AURKA, AURKB, BIRC5, CDK1, MYC |
| GO.0051276 | Chromosome organization | 5 | 0.00736 | AURKA, AURKB, CDCA8, HMGA1, MYC |
| GO.0006996 | Organelle organization | 7 | 0.00837 | AURKB, BIRC5, CDCA8, CDK1, HMGA1, INCENP, MYC |
| GO.0051781 | Positive regulation of cell division | 3 | 0.0103 | AURKA, AURKB, BIRC5 |
| GO.0035556 | Intracellular signal transduction | 6 | 0.0104 | AURKB, BIRC5, CDCA8, CDK1, INCENP, MYC |
| GO.0000086 | G2/M transition of mitotic cell cycle | 3 | 0.0122 | AURKA, BIRC5, CDK1 |
| GO.0022402 | Cell cycle process | 5 | 0.0122 | AURKB, BIRC5, CDCA8, INCENP, MYC |
| GO.1902589 | Single-organism organelle organization | 6 | 0.0131 | AURKB, BIRC5, CDCA8, CDK1, HMGA1, INCENP |
| GO.0033043 | Regulation of organelle organization | 5 | 0.0134 | AURKA, AURKB, BIRC5, HMGA1, MYC |
| GO.0090307 | Mitotic spindle assembly | 2 | 0.0136 | AURKB, BIRC5 |
| GO.0016568 | Chromatin modification | 4 | 0.0151 | AURKA, AURKB, HMGA1, MYC |
| GO.0007049 | Cell cycle | 5 | 0.026 | AURKB, BIRC5, CDCA8, INCENP, MYC |
| GO.0000075 | Cell cycle checkpoint | 3 | 0.0275 | AURKB, BIRC5, CDK1 |
| GO.0002053 | Positive regulation of mesenchymal cell proliferation | 2 | 0.0275 | MYC, MYCN |
| GO.0007098 | Centrosome cycle | 2 | 0.0275 | AURKA, CDK1 |
| GO.0090068 | Positive regulation of cell cycle process | 3 | 0.0338 | AURKA, AURKB, BIRC5 |
| GO.0031577 | Spindle checkpoint | 2 | 0.0342 | AURKB, BIRC5 |
| GO.1903047 | Mitotic cell cycle process | 4 | 0.0372 | AURKB, BIRC5, CDCA8, INCENP |
| GO.0030162 | Regulation of proteolysis | 4 | 0.0399 | AURKA, BIRC5, CDK1, MYC |
| GO.0045840 | Positive regulation of mitotic nuclear division | 2 | 0.0412 | AURKA, BIRC5 |
| GO.0051303 | Establishment of chromosome localization | 2 | 0.0434 | BIRC5, CDCA8 |
| GO.0010639 | Negative regulation of organelle organization | 3 | 0.0455 | AURKA, AURKB, HMGA1 |
As indicated, there was a strong interaction between BIRC5, HMGA1, MYC, MYCN and AURKA/B, CDK1 and CDCA8, all of which are highly affiliated with processes that drive cellular mitosis.