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. 2018 Feb 5;52(3):743–754. doi: 10.3892/ijo.2018.4265

Figure 2.

Figure 2

Circular RNA (circRNA)-000911 plays an anti-oncogenic role in breast cancer cells. (A) The expression levels of circRNA-000911 and cir-cRNA-001175 in 6 breast cancer cell lines and one normal breast epithelial cell line, MCF-10A. (B) A sketch of the structures of circRNA-000911 and mock vector is presented shown. (C) circRNA-000911 was upregulated by transfection with the circRNA vector. (D and E) circRNA-000911 significantly suppressed the proliferation rate of the (D) MCF-7 and (E) MDA-MB-231 cells. (F) The overexpression of circRNA-000911 significantly suppressed the colony formation capacity of both breast cancer cell lines. (G) FACS apoptosis assay indicated that circRNA-000911 increased the proportion of apoptotic cells in both breast cancer cell lines. (H) Wound healing and (I) Matrigel invasion assay suggested that the enhanced expression of circRNA-000911 suppressed the migratory and invasive abilities of the breast cancer cells. *P<0.05, **P<0.01 and ***P<0.001 vs. mock group.