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. 2018 Feb 5;52(3):743–754. doi: 10.3892/ijo.2018.4265

Figure 4.

Figure 4

miR-449a antagonizes circular RNA (circRNA)-000911 to regulate breast cancer progression. (A) Cell counting kit-8 (CCK-8) assay indicated that miR-449a markedly promoted the proliferation of both MCF-7 and MDA-MB-231 cells; however, the enhanced cell proliferation rate was significantly abrogated by the co-expression of circRNA-000911. (B) Matrigel invasion assay indicated that miR-449a promoted the invasive capacity of the breast cancer cells; however, circRNA-000911 suppressed the miR-449a-induced increased invasive capacity of the breast cancer cells. **P<0.01 vs. mimics group.