Extended Data Figure 8. Il-11 inhibition does not alter blood pressure after AngII treatment.
Il11ra1+/+ wild-type (n = 4 biologically independent samples) and Il11ra1−/− knockout (n = 5 biologically independent samples) mice were injected with AngII (2 mg kg−1 per day, 28 days). a, b, Systolic (a) and diastolic (b) blood pressure was measured by in vivo telemetry for one week before and four weeks after the AngII infusion. Systolic (c) and diastolic (d) blood pressure for individual mice. AngII resulted in an increase in blood pressure as expected. The genotype did not have a significant effect on blood pressure. e, Aortic root or arch velocity of the blood. There was no significant difference in the degree of aortic constriction in the TAC model between genotypes (n = 6 biologically independent samples). Two-sided Mann–Whitney U-test (e). n.s., not significant. Data are mean ± s.d. (a, b, e).