TABLE 4.
Two-way Analysis of Variance (ANOVA) of baseline hearing and IAC tumor volume on rate of hearing loss
| Baseline hearing | Normal (≤20 dB HL, n=69) | Abnormal (>20 dB HL, n=42) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline IAC tumor volume | ≤200 mm3 (n=52) | >200 mm3 (n=17) | ≤200 mm3 (n=23) | >200 mm3 (n=19) | R2 | F | p-value | ||||
| M | SD | M | SD | M | SD | M | SD | ||||
| AHDR (dB/year) | 0.7 | 2.6 | 4.3 | 6.0 | 3.6 | 3.4 | 5.0 | 5.6 | 0.18 | 7.65 | 0.0001 |
|
| |||||||||||
| Baseline 4f-PTA (dB) | 9.7 | 5.1 | 9.3 | 4.8 | 47.6 | 17.4 | 46.4 | 23.9 | |||
| Baseline IAC tumor volume (mm3) | 70.7 | 55.7 | 330.0 | 133.1 | 120.0 | 55.8 | 330.6 | 127.6 | |||
|
| |||||||||||
| Age (years) | 25.0 | 18.3 | 21.6 | 9.8 | 49.8 | 14.2 | 32.3 | 18.4 | 0.28 | 14.10 | <0.0001 |
| IAC tumor growth rate (mm3/year) | 34.4 | 35.7 | 23.1 | 21.6 | 30.7 | 49.3 | 29.4 | 43.6 | 0.01 | 0.38 | 0.768 |
| PF tumor volume (mm3) | |||||||||||
| Baseline | 41.8 | 120.9 | 201.5 | 201.7 | 85.4 | 159.5 | 128.5 | 119.4 | 0.14 | 5.82 | 0.001 |
| Growth rate (mm3/year) | 47.9 | 140.6 | 435.8 | 540.4 | 24.3 | 63.5 | 147.3 | 351.7 | 0.22 | 9.77 | <0.0001 |
| Total tumor volume (mm3) | |||||||||||
| Baseline | 112.5 | 154.2 | 531.5 | 224.2 | 205.4 | 188.8 | 459.1 | 200.5 | 0.48 | 32.42 | <0.0001 |
| Growth rate (mm3/year) | 82.3 | 160.6 | 458.9 | 550.5 | 55.0 | 74.4 | 176.6 | 362.4 | 0.19 | 8.59 | <0.0001 |
4f-PTA: Four frequency pure tone average (0.5, 1, 2, 4 kHz), AHDR: annual hearing decrease rate (dB/year), IAC: internal auditory canal, PF: posterior fossa.
R2: 0.18,
R2 adjusted: 0.133