Table 4.
Stratified analysis of the effect of prophylactic NPWT on surgical site infection, composite wound complications and wound dehiscence
| Stratification | Surgical Site Infection (pooled RR[95% CI]) | I2(%) | Composite wound complications (pooled RR [95% CI]) | I2(%) | Dehiscence (pooled RR [95% CI]) | I2 (%) |
|---|---|---|---|---|---|---|
|
| ||||||
| Estimates | ||||||
| Unadjusted | 0.45 (0.31, 0.66) | 9.9 | 0.68 (0.49, 0.94) | 44.2 | 0.86 (0.61, 1.23) | 0 |
| Adjusted* | 0.42 (0.28, 0.63) | 0 | - | - | - | - |
|
| ||||||
| Study Design | ||||||
| RCT | 0.55 (0.35, 0.87) | 4.8 | 0.82 (0.57, 1.18) | 38.6 | 0.88 (0.52, 1.50) | 7.2 |
| Cohort | 0.32 (0.18, 0.57) | 0 | 0.45 (0.26, 0.78) | 24.7 | 0.71 (0.19, 2.63) | . |
|
| ||||||
| Device | ||||||
| PICO | 0.62 (0.31, 1.26) | 46.6 | 0.69 (0.54, 0.90) | 5.8 | 1.08 (0.35, 3.31) | 21.7 |
| Prevena | 0.30 (0.12, 0.71) | 0 | 0.36 (0.19, 0.66) | 0 | 0.69 (0.27, 1.76) | 0 |
| KCI | - | 0.20 (0.01, 3.50) | . | |||
| Unknown | 0.35 (0.18, 0.68) | . | 0.90 (0.39, 2.08) | 78.3 | ||
|
| ||||||
| Reported form | ||||||
| Full-text | 0.46 (0.29, 0.72) | 8.4 | 0.66 (0.44, 0.99) | 52.5 | 0.82 (0.57, 1.19) | 0 |
| Abstract | 0.57 (0.15, 2.23) | 57.2 | 0.81 (0.32, 2.03) | 46.5 | 1.96 (0.43, 8.91) | 0 |
|
| ||||||
| Quality | ||||||
| High | 0.55 (0.35, 0.87) | 4.8 | 0.67 (0.54, 0.84) | 0.0 | 0.81 (0.28, 2.32) | 31.6 |
| Low | 0.32 (0.18, 0.57) | 0 | 0.60 (0.27, 1.32) | 74.6 | 0.91 (0.32, 2.60) | 0 |
*
Denotes the adjusted OR