. 2017 Dec 29;57(4):192–202. doi: 10.1002/gcc.22520

Table 2.

Significant miRNA‐TF‐TG interactions identified in normal colonic mucosa

	Mean expression				Mean expression				Mean expression				P‐Value
miRNA	Tumor^a	Normal	miRNABeta Co.	TF	Tumor^a	Normal	TFBeta Co.	TG	Tumor^a	Normal	miRNA*TF(interaction)Beta Co.^b	miRNA‐TFBeta Co.^c	Raw	FDR
hsa‐miR‐1258	1.75	3.92	0.03	ZNF263 ^d	95.39	44.41	0.68	CPM ^d	33.18	122.94	0.28	−0.23	<.0001	0.0177
hsa‐miR‐145‐5p	134.57	207.91	0.18	CTCF	135.97	72.45	0.72	IGF1R ^d	365.93	187.47	0.15	0.21	0.0003	0.0228
hsa‐miR‐145‐5p	134.57	207.91	0.18	ELF1	250.60	119.97	0.77	IGF1R ^d	365.93	187.47	0.15	0.21	<.0001	0.0177
hsa‐miR‐150‐5p	15.27	40.22	−0.17	CTCF	135.97	72.45	0.75	VEGFA ^d	971.21	369.26	−0.20	0.24	0.0008	0.0354
hsa‐miR‐150‐5p	15.27	40.22	−0.16	ELF1	250.60	119.97	0.81	VEGFA ^d	971.21	369.26	−0.23	0.22	<.0001	0.0177
hsa‐miR‐193b‐3p	8.76	5.08	−0.12	CTCF	135.97	72.45	0.70	RRM2 ^d	172.47	37.43	−0.28	0.24	0.0003	0.0228
hsa‐miR‐193b‐3p	8.76	5.08	−0.13	RBBP5	79.50	39.15	0.83	HELLS	268.00	82.11	−0.26	0.27	0.0002	0.0212
hsa‐miR‐193b‐3p	8.76	5.08	−0.07	RBBP5	79.50	39.15	0.94	MAPK1IP1L ^d	270.04	167.11	−0.14	0.27	0.0002	0.0212
hsa‐miR‐193b‐3p	8.76	5.08	−0.12	RBBP5	79.50	39.15	0.74	RAD51 ^d	20.32	9.74	−0.23	0.27	0.0007	0.0338
hsa‐miR‐193b‐3p	8.76	5.08	−0.04	RBBP5	79.50	39.15	0.82	RCC1	137.97	46.22	−0.21	0.27	0.0006	0.0319
hsa‐miR‐193b‐3p	8.76	5.08	−0.05	RBBP5	79.50	39.15	0.87	TJP2	412.82	182.83	−0.19	0.27	0.0004	0.0265
hsa‐miR‐330‐3p	2.71	5.56	−0.08	ELF1 ^d	250.60	119.97	0.77	PTPLAD1 ^d	216.84	55.26	−0.19	−0.19	0.0005	0.0295
hsa‐miR‐4469	0.97	2.40	−0.09	ELF1 ^d	250.60	119.97	0.83	MRPS27 ^d	140.87	57.30	−0.14	−0.26	0.0009	0.0368

This table has been split into four groupings based on the directionality of the different beta coefficients. This has been done to assist in interpretation and following the discussion.

Tumor expression is shown for additional information only, and is not used in the calculation of any results in this table.

This beta coefficient was generated from the two‐way interaction analysis.

This beta coefficient was calculated in a separate linear regression between the miRNA and TF.

A seed match was identified between this TG and the miRNA.