. Author manuscript; available in PMC: 2019 Mar 1.

Published in final edited form as: Addiction. 2017 Nov 2;113(3):509–523. doi: 10.1111/add.14032

Table 3.

The variants tagging the top two independent signals from the meta-analysis of conditional analyses in PNAT2 and KIS3 African American smokers

Variant	Gene/location	Ref. Allele	Test Allele	MAF (%) in PNAT2	MAF (%) in KIS3	Beta (SE); P-Value in PNAT2^a	Beta (SE); P-Value in KIS3^a	Beta (SE); P-Value in Meta-Analysis^b
rs12459249	~9.5kb 3’ of CYP2A6	T	C	31.2	35.9	0.60 (0.063); 1.16e-19	0.61 (0.064); 1.21e-19	0.59 (0.045); 1.47e-39
rs111645190	~5.5kb 5’ of CYP2A6	G	A	13.7	14.2	-0.63 (0.088); 3.29e-12	-0.65 (0.089); 1.57e-12	-0.62 (0.06); 1.06e-23

MAF, minor allele frequency

Adjusted for cohort-specific principal components 1 and 2

In PNAT2, GWAS results were adjusted for principal components 1 and 2, sex, age, BMI, and the use of mentholated cigarettes. In KIS3, GWAS results were adjusted for principal components 1 and 2, sex, age, and BMI. The genomic inflation factor score (λ) in each population was 1 and therefore not adjusted for in the meta-analysis.