Skip to main content
. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: J Neurooncol. 2017 Nov 23;136(3):475–484. doi: 10.1007/s11060-017-2681-8

Figure 3.

Figure 3

Distribution of fluorescently labeled liposomal CPT-11 by IND in normal brain and brainstem tumor. A. Fluorescent signals were detected from olfactory bulb throughout the different brain regions. B. 1 × 105 luciferase-modified GS2 glioblastoma cells were injected into brainstem in athymic rats using an implantable guide-screw system. Bioluminescence imaging (BLI) shows a corresponding signal from the brainstem tumor (upper). Histologic analysis reveals GS2 tumor growth in the pons (middle: 2 × magnification, lower: 40 × magnification). C. Fluorescent labeled liposomal CPT-11 accumulated in the brainstem 6 hours following IND.