Table 2.
Antibacterial activities of fluoroquinolones in P. aeruginosa cells with intact and hyperporinated outer membranes carrying the plasmid borne MexEF-OprN and MexG/HI-OpmD.
| FQs | MICs, μM
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| PAO1 | PΔ4 | PΔ4MexEF-OprN | PΔ4 MexHI-OpmD | PΔ4 MexGHI-OpmD | PΔ4-Pore | PΔ4-Pore MexEF-OprN | PΔ4-Pore MexHI-OpmD | PΔ4-Pore MexGHI-OpmD | |
| Ciprofloxacin | 0.39 | 0.02 | 1.25 | 1.25 | 0.625 | 0.005 | 0.16 | 0.08 | 0.04 |
| Enrofloxacin | 1 | 0.04 | 5 | 5 | 1.25 | 0.005 | 0.31 | 0.16 | 0.04 |
| Levofloxacin | 1 | 0.02 | 1.25 | 2.5 | 1.25 | 0.005 | 0.16 | 0.04 | 0.04 |
| Gatifloxacin | 1 | 0.04 | 2.5 | 2.5 | 1.25 | 0.002 | 0.16 | 0.04 | 0.02 |
| Moxifloxacin | 6.25 | 0.04 | 5 | 2.5 | 0.313 | 0.002 | 0.31 | 0.04 | 0.005 |
| Prulifloxacin | 0.25 | 0.01 | 0.313 | 0.313 | 0.156 | 0.003 | 0.08 | 0.02 | 0.01 |
| Sparfloxacin | 1 | 0.04 | 2.5 | 5 | 2.5 | 0.001 | 0.08 | 0.08 | 0.02 |
| Difloxacin | 1.56 | 0.04 | 5 | 2.5 | 0.625 | 0.002 | 0.16 | 0.04 | 0.02 |
| Lomefloxacin | 1.56 | 0.08 | 5 | 5 | 2.5 | 0.01 | 0.31 | 0.31 | 0.08 |
| Ofloxacin | 1.56 | 0.08 | 5 | 5 | 2.5 | 0.01 | 0.31 | 0.16 | 0.08 |
| Pazufloxacin | 1 | 0.04 | 2.5 | 1.25 | 0.625 | 0.01 | 0.16 | 0.08 | 0.04 |
| Norfloxacin | 1 | 0.04 | 2.5 | 1.25 | 1.25 | 0.02 | 0.63 | 0.08 | 0.08 |
| Pefloxacin | 1 | 0.09 | 5 | 5 | 2.5 | 0.02 | 1.25 | 0.16 | 0.16 |
| Sarafloxacin | 0.39 | 0.02 | 1.25 | 0.625 | 0.313 | 0.005 | 0.08 | 0.02 | 0.02 |
| Nadifloxacin | 6.25 | 0.08 | 5 | 5 | 2.5 | 0.001 | 0.16 | 0.08 | 0.08 |