Table 3.
The contributions of MexEF-OprN and MexG/HI-OpmD in P. aeruginosa susceptibility to phenazines and antibiotics.
| MIC, μM | Pyocyanin | PMS | Chloramphenicol | Ciprofloxacin | |||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Genotype | - | Pore | - | Pore | - | Pore | - | Pore | |
| PΔ4 | EF+, GHI+ | 1000 | 250 | 500 | 62.5 | 3.1 | 1.6 | 0.001 | 0.0002 |
| PΔ4ΔG | EF+, GHI− | 250 | 31.25 | 31.3 | 31.3 | 12.4 | 1.6 | 0.004 | 0.0002 |
| PΔ5 | EF−, GHI+ | >1000 | 250 | 500 | 25 | 3.1 | 1.6 | 0.001 | 0.0002 |
| PΔ6 | EF−, GHI+ | >1000 | 125 | 500 | 125 | 1.6 | 1.6 | 0.001 | 0.0002 |
| PΔ6ΔG | EF−, GHI− | 31.3 | 31.3 | 31.3 | 15.6 | 1.6 | 1.6 | 0.0002 | 0.0001 |
| PΔ6ΔG(pMexEF-OprN) | EF↑, GHI− | >500 | 125 | 500 | 31.25 | >256 | 3.1 | 0.4 | 0.012 |
| PΔ6ΔG(pMexHI-OpmD) | EF−, HI↑ | >500 | 1000 | 2000 | 125 | 1.6 | 0.8 | 0.4 | 0.012 |
| PΔ6ΔG(pMexGHI-OpmD) | EF−, GHI↑ | >500 | 500 | 1000 | 62.5 | 1.6 | 0.8 | 0.2 | 0.012 |