Table 1.
Characteristics of the Study Population at Time of First Bone Density Assessment (Baseline)
| Women (N=839) | Men (N=1759) | |
|---|---|---|
| Baseline Characteristics | N (%) or Median (IQR) | |
| Age >55 years | 37 (4) | 166 (9) |
| 51–55 years | 71 (9) | 197 (11) |
| 46–50 years | 183 (22) | 450 (26) |
| 41–45 years | 303 (36) | 536 (31) |
| 35–40 years | 182 (22) | 265 (15) |
| <35 years | 63 (8) | 145 (8) |
| Body mass index (median, IQR) | 21.6 (20.0, 24.1) | 23.5 (21.6, 25.5) |
| Smoking (pack years median, IQR) | 10.0, (1.1, 20.0) | 12.5 (0, 25.0) |
| Physical activity | ||
| None | 577 (69) | 1020 (58) |
| Moderate | 184 (22) | 438 (25) |
| Vigorous | 44 (5) | 224 (13) |
| Post-Menopausal | 124 (15) | – |
| Hypogonadism | – | 124 (7) |
| Metabolic Syndrome | 84 (10) | 144 (8) |
| Hepatitis C Virus | 250 (30) | 468 (27) |
| Vitamin D Insufficiency | 414 (49) | 831 (47) |
| History of AIDS Wasting | 113 (13) | 81 (5) |
| CD4 Nadir <200 cells/μL | 448 (53) | 856 (49) |
| HIV-1 VL ≤50 | 646 (77) | 1319 (75) |
| ART duration (years) | 9.6 (5.6, 13.1) | 8.3 (3.4, 12.0) |
| TDF use | 538 (64) | 1144 (65) |
| INSTI use | 70 (8) | 129 (7) |
| Total BMD | 1.009 (0.116) | 1.162 (0.115) |
| Femoral Neck BMD | 0.816 (0.154) | 0.842 (0.152) |
| Lumbar Spine BMD | 1.057 (0.170) | 1.054 (0.167) |
BMD, bone mineral density; Vitamin D insufficiency <30 ng/mL; TDF, tenofovir disoproxil fumarate; INSTI, integrase strand transfer inhibitor