Figure 4.
Adolescent CVSS decreased adult nicotine consumption in male, but not female mice. Data (mean ± SEM) represent average 24 h nicotine consumption of male (A & E) and female (B & F) mice and preference for nicotine of male (C & G) and female (D & H) mice during experiment 1 (A–D) and 2 (E–H). # denotes a significant nicotine concentration × stress condition interaction in males (p < 0.05). * denotes a significant nicotine concentration x stress condition interaction in both sexes (p < 0.05). (Experiment 1: N=11–15/group, Experiment 2: N=9–12/group).