Table 2.
Chemical structures and bioactivities of NPD8716 and its analogs. IC50s for inhibiting HBV infection and NTCP-mediated bile acid uptake are shown on the second and the third columns, respectively. CC50s determined by MTT assay are also shown in the fourth column. IC50s and CC50s are shown in μM.
| name & structure | IC50 (HBV infection) | IC50 (NTCP transporter) | CC50 |
|---|---|---|---|
NPD8716 
|
238 ± 23.6 | 17.8 ± 1.1 | >270 |
NPD3980 
|
194 ± 22.7 | 34.9 ± 12.3 | >270 |
NPD13325 
|
145 ± 9.5 | 12.5 ± 1.5 | >270 |
NPD4939 
|
123 ± 7.4 | 16.2 ± 1.4 | >270 |
NPD11375 
|
150 ± 11.3 | 13.3 ± 1.9 | >270 |