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. 2018 Feb 9;8:2722. doi: 10.1038/s41598-018-21130-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MAP2 protein accumulated within spheroids. (A and B) The cerebellar sections of Elavl3^+/+ and Elavl3^−/− mice at 6 months of age were immunostained with anti-MAP2 and calbindin antibodies. Confocal microscopic analysis showed that spheroids in the granule cell layer (A) and swollen axonal terminals in the cerebellar nuclei (B) were stained with MAP2. Boxed regions in (A) and (B) are enlarged as orthogonal projections in bottom and right panels, respectively. Somata of cerebellar nuclei neurons in (B) are demarcated by a white line. Scale bars: A, 10 μm; B, 5 μm. (C) Ultrastructures of cerebellar nuclei of 5-months-old Elavl3^−/− mice were analyzed via transmission electron microscopy. A cerebellar nuclei neuron is pseudo-colored yellow and abnormal structures are pseudo-colored red. Boxed regions are enlarged in right panels. Scale bar, 1 μm.