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. 2018 Feb 9;8:2689. doi: 10.1038/s41598-018-20612-w

Table 4.

Recommended reference genes for RT-qPCR Analysis in Coleoptera.

Species Biotic Conditions Abiotic Conditions Others
Dev. Stage* Tissue Sex Temperature Photoperiod RNAi
Coccinellidae
  Harmonia axyridis (this study) 18S, HSP70, 28S 28S, 18S, Rp49/RpL32 HSP90, Rp49/RpL32, HSP70 18S, 28S, GAPDH 18S, 28S, HSP90 Rp49/RpL32, ATP1A1, 28S
  Hippodamia convergens45 28S, EF1A, CypA GAPDH, 28S, CypA GAPDH, CypA, 28S EF1A, 28S, ATP6V1A CypA, GAPDH, ATP6V1A CpyA, Actin, GAPDH
  Coleomegilla maculate46 ATP6V1A, RPS18, EF1A NA** 16S, HSP70, RpS18 18S, TUBA, 12S NA 18S, 16S, 12S
  Coccinella septempunctata47 16S, 28S, NADH 28S, 16S, 18S NA NA NA ACTB, TUBA, EF1A
Chrysomelidae
  Diabrotica virgifera virgifera57 ACTB, EF1A, RpS9 EF1A, GAPDH, TUBB NA NA NA RpS9, EF1A, GAPDH EF1A, GAPDH, TUBB
(Bt)
  Leptinotarsa decemlineata58 RP18, ARF1, RP4 RP18, ARF1, RP4 NA NA NA NA RP18, RP4, ARF1 (Insecticide)
  Galeruca daurica59 SDHA, Rp49/RpL32, GST SDHA, TUBA, Rp49/RpL32 ACTB, TUBA, SDHA SDHA, TUBA, ACTB NA NA SDHA, TUBA, GAPDH (Diapause)
Cerambycidae
  Anoplophora glabripennis60 NA Rp49/RpL32, GAPDH, SDF (Adults) NA NA NA NA GAPDH, UBQ, Rp49/RpL32 (Larvae)
Tenebrionidae
  Tribolium castaneum61,62 NA NA NA NA NA NA RPS3, RPS18, RPL13a (Fungus)
RpL13A, RpS3, ACTB (UV)
Meloidae
  Mylabris cichorii63 NA NA TAF5, UBE3A, RPL22e (Male) NA NA NA UBE3A, RPL22e, TAF5 (Female)

*Developmental stages.

**Not Applicable. Please note that the abbreviation of gene names may differ among the cited references.