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. 2018 Feb 9;8:2777. doi: 10.1038/s41598-018-20642-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential DNA methylation, BAV and TAV dilated (D) ascending aortas. (a) Principle component analysis of BAV (pink) and TAV (blue) DNA methylation using M-values; (b) Volcano plot of −log10 (P-value) against log2 (fold-change) of beta values, representing differential methylation between BAV and TAV (t-test). Dashed line represents the Bonferroni-adjusted threshold for statistical significance; (c) mean DNA methylation, presented as (%) ± standard deviation (t-test). *P ≤ 0.05. N = 14 BAV and N = 13 TAV.