Table 1.
Hallmark and KEGG pathway analysis of BAV vs. TAV hypomethylated DMR-associated genes, non-dilated aorta. Age-corrected methylation values.
| Gene Set Name | FDR q | |
|---|---|---|
| Hallmark Analysis | ||
| Estrogen response, late | Genes defining late response to estrogen. | 7.21E-8 |
| TNF signaling via NFKB | Genes regulated by NF-kB in response to TNF. | 2.82E-7 |
| Hypoxia | Genes up-regulated in response to low oxygen levels. | 1.37E-6 |
| Estrogen response, early | Genes defining early response to estrogen. | 6.95E-6 |
| Epithelial mesenchymal transition (EMT) | Genes defining EMT as in wound healing, fibrosis and metastasis. | 3.48E-5 |
| TGFβ signaling | Genes up-regulated in response to TGFB1. | 2.77E-4 |
| Apoptosis | Genes mediating programmed cell death by activation of caspases. | 6.54E-4 |
| IL2/STAT5 signaling | Genes up-regulated by STAT5 in response to IL2 stimulation. | 6.54E-4 |
| Peroxisome | Genes encoding components of peroxisome. | 1.05E-3 |
| Reactive oxygen species pathway | Genes up-regulated by reactive oxygen species. | 1.15E-3 |
| KEGG pathway Analysis | ||
| Pathways in cancer | — | 1.72E-6 |
| Insulin signaling pathway | — | 5.59E-6 |
| Hypertrophic cardiomyopathy | — | 3.38E-5 |
| Chronic myeloid leukemia | — | 8.36E-5 |
| WNT signaling pathway | — | 3.54E-4 |
| Regulation of actin cytoskeleton | — | 1.25E-3 |
| Endocytosis | — | 1.33E-3 |
| Focal adhesion | — | 2.35E-3 |
| Adipocytokine signaling pathway | 2.35E-3 | |
| Calcium signaling pathway | — | 3.93E-3 |