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. 2018 Feb 5;9:128. doi: 10.3389/fimmu.2018.00128

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Copyright © 2018 Hong, Wu, Li, Wang, Wen, Jiang, Dimitrov and Ying.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The characteristics of CDRs in the IgH repertoire of the neonates and the adults. (A) The CDR1 length distribution. (B) The CDR2 length distribution. (C) The CDR3 length distribution. (D) The occurrence of amino acids changes in CDR1 regions. “Without” represented no amino acids changes, and “With” represented at less one amino acid change happened when compared to the germline IgH gene. (E) The occurrence of amino acids changes in CDR2 regions. (F) The amino acids usage of CDR3 sequences.