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. 2018 Feb 5;11:25. doi: 10.3389/fnmol.2018.00025

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Copyright © 2018 Filošević, Al-samarai and Andretić Waldowski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multiple exposures to cocaine increases locomotor activity of a population, while sensitivity of individual flies does not change. (A) Kinetic graph of mean locomotion (counts/minute) for group of flies (n = 32) both before (bsl) administration, and after exposure to volatilized 45 μg cocaine on three occasions: the first at 09:00 AM (1st), the second at 07:00 PM (2nd) and the third at 09:00 AM of the next day (3rd). The light gray panel indicates the 5 min immediately prior to exposure, the dotted line is the time of exposure and the dark gray panel indicates 5 min after exposure. (B) Analysis of individual flies from data in part (A). Percentage of individual flies in population which show sensitivity (SENS) and locomotor sensitization (LS). Starting data were same as (A) from which categories increase, decrease and same were divided.