FIGURE 8.

Locomotor sensitization to vCOC is dependent on a functional dopaminergic transporter. (A) Average locomotor activity (counts/min) during baseline, 5 min before drug exposures (bsl), 5 min after first exposure (1st) and 5 min after 2nd) exposure to 75 μg of vCOC given 6 h apart for a population of wild type (wt), and flies mutant in dopaminergic transporter, fumin (fmn) (n = 32 for each group). Statistical significance p ≤ 0.05; c: comparison of baseline to after first administration, d: after first to after second and e: baseline to after second administration (all within the group using t-test for dependent samples). (B) Percent of individual flies increasing locomotor activity to first exposure of vCOC (bsl vs. 1st) and flies showing further increase in locomotor activity to the second exposure (LS) (bsl vs. 1st vs. 2nd). χ² test showed statistical significance p ≤ 0.05 (^∗) for wt compared to fmn in LS. Starting data were same as (A) from which categories increase, decrease and same were divided.