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. 2018 Feb 5;12:28. doi: 10.3389/fncel.2018.00028

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Copyright © 2018 Gerrard, Tantirigama and Bekkers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Properties of a postsynaptic GABA_B receptor-mediated response in semilunar (SL) and superficial pyramidal (SP) cells in layer 2 of the piriform cortex (PC). Inset at top shows a schematic of the experiment configuration. LOT, lateral olfactory tract. (A) Layer 1 stimulation (five pulses at 100 Hz) evokes a slow hyperpolarization (black trace) that is blocked by 5 μM CGP55845 (red; each trace is an average of 10 episodes; SP cell shown). (B) Mean peak amplitude of the postsynaptic GABA_B receptor response, normalized to the mean amplitude during the baseline period, plotted vs. time (n = 7 SL and SP cells). Normalized amplitude decreases after bath application of CGP55845 (red bar). Error bars show ± SEM. (C) Typical voltage-clamp experiment for determining the reversal potential of the GABA_B-mediated postsynaptic current. Each trace is an average of four episodes, each at the indicated holding potential. Stimulus as in (A). Data are from an SP cell. (D) Mean current-voltage plot for the cell in (C). Blue line is a linear fit, giving an estimated reversal potential of −91 mV in this example. Error bars show ± SD.