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. 2018 Feb 9;8:2760. doi: 10.1038/s41598-018-21157-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Interaction with the plasmamembrane of GT1-7 cells and internalization of 50 nm SiO₂ NPs. (a) Low magnification TEM image of a GT1-7 cell with NPs on the plasmamembrane and in a vescicle (2 hours incubation). Scale bar: 500 nm. (b) After either 1 or 2 hours of incubation, small agglomerates of NPs could be observed in association with the plasmamembrane; some of them were already incorporated into endocytic vesicles. Scale bars: 100 nm. (c) NPs density obtained by TEM images at 1 and 2 hrs of incubation. Mann-Whitney U test; ***p < 0.0001 two-tailed, n = 3. (d) Quantitative assessment of internalization at 1 and 24 hours of incubation by means of ICP-MS. t-test, *p = 0.037 two-tailed, n = 4.