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. 2018 Feb 9;8:2694. doi: 10.1038/s41598-018-20451-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plumbagin treatment causes RNA degradation. (a) Total RNA from PTEN-P2 cells was isolated 0, 1, or 24 hr. after treatment with 0.5, 1.5, or 4.0 μM plumbagin and resolved on agarose gels. The two bands correspond to the ribosomal RNAs large and small subunits. (b) Bar graph of ethidium bromide fluorescence of large ribosomal subunit rRNA showing that plumbagin causes RNA degradation over time in proportion to the plumbagin concentration. Error bars represent one standard deviation, n = 2. (c) RNA from PTEN-P2 cells exposed to plumbagin at 1.5 μM for 25 hr, or DHT (10⁻⁸ M) for 48 hr or both.