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. 2018 Feb 5;11:736. doi: 10.3389/fnins.2017.00736

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Copyright © 2018 Naphade, Embusch, Madushani, Ring and Ellerby.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased MMP-14 expression in HD-NSCs. (A) Western blot analysis of MMP-14 shows a significantly decreased expression of MMP-14 in HD-NSCs. MMP-14 immunoreactivity was quantified by densitometry and normalized for α-tubulin immunoreactivity (n = 3 BR, ^*p < 0.05; t-test). Error bars represent SD. (B) Immunofluorescence analysis of MMP-14 not only confirms decreased expression in HD vs. C116-NSCs, but also reveals predominantly nuclear expression of MMP-14 in HD-NSCs which possibly associates with nuclear mHTT expression (40X magnified insets). Scale Bars: 20X = 100 μm, 40X = 50 μm.