Table 3.
Metal transporters regulating MAPK signaling and vice versa.
| Family | Metal transporter | Metal ions | MAPKs | Model organism | Reference | |
|---|---|---|---|---|---|---|
| METAL TRANSPORTERS REGULATING MAPKs | ||||||
| 1 | ZIP family | ZIP9/SLC39A9 | Zn | ERK MAPKs | Chicken | Taniguchi et al., 2013 |
| 2 | NRAMP family | NRAMP1 (SLC11A1) | – | P38MAPK | Mammals | Moisan et al., 2006 |
| 3 | CTR family | CTR1 | Cu | MEK1-ERK1 | Mammals | Tsai et al., 2012; Turski et al., 2012 |
| 4 | CDF family | ZnT1 | Zn, Co, Cd | Raf1-MEK-ERK | C. elegans | Jirakulaporn and Muslin, 2004 |
| 5 | Metallothioneins | Zn | P38 MAPK | Mammals | Rice et al., 2016 | |
| MAPKs REGULATING METAL TRANSPORTERS | ||||||
| 1 | ZIP family | IRT1 | Fe | MPK3, MPK6 | Arabidopsis | Ye et al., 2015 |
| 2 | NRAMP family | NRAMP1 | – | P38MAPK, p42/44 MAPK | Mammals | Zhang et al., 2000 |
| 3 | ABC family | MRP1 | – | ERK/MAPK pathway | Mammals | El Azreq et al., 2012 |
| 4 | ABCA1, ABCG1 | Ras-MAPK pathway | Mammals | Mulay et al., 2013 | ||
| 5 | Zn transporter family | Zrc1 | Zn | Pbs2-Hog1-RCK1/RCK2 | Yeast | Bilsland et al., 2004 |
| 6 | Phytochelatins | – | Unknown MAPK | S. mansoni | Rigouin et al., 2013 | |