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. 2018 Feb 9;3:3. doi: 10.1038/s41536-018-0042-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — (a) Raw spectra of native and engineered cartilage. Raman spectroscopic image (univariate analysis) of ECM heterogeneities in 56-day cultured large engineered cartilage tissue construct (∅6 mm × 3 mm) for (b) the full cross-section (10 μm spatial resolution) and (c) a localized peripheral region (1 μm resolution). Arrows represent media-exposed surfaces. (d) Raman spectroscopic image of natural depth dependent ECM heterogeneities in native articular cartilage (10 μm resolution). Arrow represents articular surface