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. 2018 Feb 9;8:2743. doi: 10.1038/s41598-018-20856-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Abnormal mitochondria in mouse and human PKD cells and tissues. (a) Electron microscopy showing swollen mitochondria, some with darkly stained membranous whorls, in mutant cells. (b) Swollen mitochondria in mutant cells freshly dissociated from cystic and control mouse kidneys. Panels on the right show higher magnification of the areas inside the white squares. (c) Quantification of number of “normal” or “aberrant” mitochondria in randomly selected fields of the samples shown in (a and b); n ≥ 29 fields/condition, p < 0.001. (d) Swollen mitochondria in ADPKD human kidney samples. Panels on the right show higher magnification of the areas inside the white squares. Representative aberrant mitochondria are indicated with magenta arrowheads.