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. 2018 Feb 9;8:2758. doi: 10.1038/s41598-018-21141-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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UM-C162 improves the lifespan of S. aureus-infected nematodes without affecting bacterial growth. (a) UM-C162 does not inhibit the growth of S. aureus in the presence of 6.25 µM, 12.5 µM and 25 µM UM-C162. (b) Survival curves of S. aureus-infected C. elegans treated with 6.25 µM, 12.5 µM and 25 µM of UM-C162 compared to untreated control (0 µM). UM-C162 at all concentrations tested confers significant enhanced survival in infected nematodes (p < 0.0001). (c) UM-C162 does not alter the basal lifespan of worms fed on heat killed E. coli OP50. Graphs in (b) and (c) show the mean ± SD of six technical replicates (20 worms/replicate) from a representative of two independent experiments.