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. 2018 Feb 9;8:2758. doi: 10.1038/s41598-018-21141-2

Figure 8.

Figure 8

General synthesis of benzimidazole derivatives. Reaction conditions: For R1 = OCH3 (i) HATU, DIPEA, DMF (ii) AcOH, 110 °C (iii) LiOH, MeOH/THF (iv) HOBt, EDCl, NH4Cl, DIPEA, DMF; For R1 = NH2 (i) CDI, pyridine, DMF (ii) AcOH, 110 °C.