Table 1.
A description of the demographic and tumor characteristics in the matched cohort
| Demographic and tumor characteristics | Women exposed to fertility preservation requiring hormonal stimulation | Women exposed to fertility preservation with no need for hormonal stimulation | Matched comparators (unexposed to fertility preservation) |
|||
|---|---|---|---|---|---|---|
| n | Relapses (%) | n | Relapses (%) | n | Relapses (%) | |
| Total | 148 | 16 (10.8) | 40 | 9 (22.5) | 378 | 104 (27.5) |
| Age at diagnosis (years) | ||||||
| Mean (range) | 32.7 (21–42) | – | 32.0 (23–38) | – | 34.1 (23–42) | – |
| Year of diagnosis | ||||||
| 1997–2002 2003–2007 2008–2013 |
12 (8.1) 29 (19.6) 107 (72.3) |
4 (33.3) 6 (20.7) 6 (5.6) |
9 (22.5) 18 (45.0) 13 (32.5) |
3 (33.3) 4 (22.2) 2 (15.4) |
118 (31.2) 125 (33.1) 135 (35.7) |
60 (50.1) 31 (24.8) 13 (9.6) |
| Tumor size | ||||||
| T0 TIS I (≤ 20 mm) II (21–50 mm) III (≥ 50 mm) TX |
5 (3.4) 1 (0.7) 79 (53.4) 55 (37.2) 17 (4.7) 1 (0.7) |
0 (0.0) 1 (100.0) 6 (7.6) 9 (16.4) 0 (0.0) 0 (0.0) |
1 (2.5) 1 (2.5) 20 (50.0) 12 (30.0) 4 (10.0) 2 (5.0) |
0 (0.0) 0 (0.0) 5 (25.0) 3 (25.0) 1 (25.0) 0 (0.0) |
25 (6.6) 1 (0.3) 158 (41.8) 144 (38.1) 46 (12.2) 4 (1.1) |
1 (4.0) 0 (0.0) 41 (26.0) 47 (32.6) 15 (32.6) 0 (0.0) |
| Lymph nodes | ||||||
| 0 1–3 > 3 Missing |
95 (64.2) 40 (27.0) 12 (8.1) 1 (0.7) |
8 (8.4) 5 (12.5) 3 (25.0) 0 (0.0) |
20 (50.0) 12 (30.0) 7 (17.5) 1 (2.5) |
4 (20.0) 3 (25.0) 2 (28.6) 0 (0.0) |
204 (54.0) 104 (27.5) 52 (13.8) 18 (4.8) |
41 (20.1) 32 (30.1) 27 (51.9) 4 (22.2) |
| Receptors | ||||||
| ER+ ER− ER missing |
103 (69.6) 44 (29.7) 1 (0.7) |
11 (11.0) 4 (9.3) 1 (100.0) |
25 (62.5) 14 (35.0) 1 (2.5) |
5 (20.0) 4 (28.6) 0 (0.0) |
243 (64.3) 125 (33.1) 10 (2.7) |
67 (27.6) 35 (28.0) 2 (20.0) |
| Laterality | ||||||
| Right Left Missing |
67 (45.3) 79 (53.4) 2 (1.4) |
4 (6.0) 12 (15.2) 0 (0.0) |
15 (37.5) 24 (60.0) 1 (2.5) |
3 (20.0) 6 (25.0) 0 (0.0) |
188 (49.7) 190 (50.3) 0 (0.0) |
55 (29.3) 49 (25.8) 0 (0.0) |
| Neoadjuvant treatment | ||||||
| No Yes Missing |
123 (83.1) 23 (15.5) 2 (1.4) |
15 (12.2) 1 (4.4) 0 (0.0) |
29 (72.5) 10 (25.0) 1 (2.5) |
7 (24.1) 2 (20.0) 0 (0.0) |
291 (77.0) 87 (23.0) 0 (0.0) |
70 (24.1) 34 (39.1) 0 (0.0) |
| Chemotherapy | ||||||
| No Yes |
19 (12.8) 129 (87.2) |
2 (10.5) 14 (10.9) |
5 (12.5) 35 (87.5) |
2 (40.0) 7 (20.0) |
98 (25.9) 280 (74.1) |
25 (25.5) 79 (28.2) |
ER estrogen receptor