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. 2018 Feb 9;8:2729. doi: 10.1038/s41598-018-20740-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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cTfh responses induced by oral ETEC vaccination correlated with blood plasmablast and vaccine specific ALS responses. Correlation between the magnitudes (fold rises) of activated cTfh cell (ICOS⁺CD4⁺CXCR5⁺) and (a) IgA⁺ plasmablast (IgA⁺CD27⁺CD38^hiCD19⁺) responses and (b) the combined response index of vaccine specific IgA ALS responses against the five major vaccine antigens. Each symbol represents one individual; n = 31 in (a) (18 subjects from the primary and 13 from the booster vaccination study) and n = 34 in (b) (20 subjects from the primary and 14 from the booster vaccination study) and data is displayed in a log-log scale plot.