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. 2018 Feb 9;8:2717. doi: 10.1038/s41598-018-21252-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of peripheral administration of an adenosine A1 receptor agonist, N6-cyclohexyladenosine (CHA), on body temperature. (A) Time-related changes in body temperature. Open symbols represent the data from wild-type mice (WT) and closed symbols from orexin neuron-ablated mice (AB). Circle, triangle, and square symbols indicate 2, 20, 200 nmol of CHA, respectively. CHA was intraperitoneally injected at time 0. (B) Changes in body temperature (BT) averaged for 6 hours after the injection. 2-way ANOVA indicated there was statistical difference among doses (F_2,30 = 160.0, p < 0.0001) but not between genotypes (F_1,30 = 4.11, p = 0.052). P values were calculated using the Holm-Sidak multiple comparison test. Each point represents mean ± SEM from 6 animals.