Table 1.
National Toxicology Program 74 compound plate – agents scored as damaging by CometChip (in descending order by mean % tail DNA within each category). (P value was calculated using a one tailed Student’s t-test).
| Chemical Name | CAS # | Plate Position | A priori designation | P Value |
|---|---|---|---|---|
| Thiram | 137-26-8 | B9 | Known genotoxicant | P < 0.0001 |
| Hydroquinone | 123-31-9 | A9 | Known genotoxicant | P < 0.0001 |
| 2-Aminoanthraquinone | 117-79-3 | D9 | Known genotoxicant | P < 0.0001 |
| Cadmium chloride | 10108-64-2 | C4 | Known genotoxicant | P < 0.0001 |
| D&C Yellow 11 | 8003-22-3 | F11 | Known genotoxicant | P < 0.0001 |
| N-Methyl-N’-nitro-N-nitrosoguanidine (MNNG) | 70-25-7 | G2 | Known genotoxicant | P < 0.0001 |
| Sodium dichromate(VI) dihydrate | 7789-12-0 | C5 | Known genotoxicant | P < 0.0001 |
| Styrene oxide | 96-09-3 | C7 | Known genotoxicant | P < 0.0001 |
| 2,4-diaminotoluene | 95-80-7 | C8 | Known genotoxicant | P < 0.0001 |
| Adriamycin HCl (a.k.a. Doxorubicin HCl) | 25316-40-9 | A3 | Known genotoxicant | P < 0.0001 |
| 1-Ethyl-1-nitrosourea (ENU) | 759-73-9 | C2 | Known genotoxicant | P < 0.0001 |
| Diethylstilbestrol | 56-53-1 | D7 | Known genotoxicant | P < 0.05 |
| Trichloroethylene | 79-01-6 | A2 | Known genotoxicant | P < 0.05 |
| Malachite green oxalate | 2437-29-8 | A7 | Possible genotoxicant | P < 0.0001 |
| Tribromoacetaldehyde | 115-17-3 | F9 | Possible genotoxicant | P < 0.0001 |
| Copper dimethyldithiocarbamate | 137-29-1 | F8 | Possible genotoxicant | P < 0.0001 |
| Zinc dibutyldithiocarbamate | 136-23-2 | A6 | Possible genotoxicant | P < 0.0001 |
| 2,4-Di-tert-butylphenol | 96-76-4 | E1 | Possible genotoxicant | P < 0.0001 |
| Poly(oxy-1,2-ethanediyl),.alpha.-hydro-.omega.-[(1-oxo-2-propenyl)oxy]-, ether with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (3:1) | 28961-43-5 | F10 | Possible genotoxicant | P < 0.0001 |
| 3-Butyl-1-nitro-3-nitrosoguanidine | 13010-08-7 | E11 | Possible genotoxicant | P < 0.0001 |
| 1-Methyl-3-tetradecylimidazolium chloride | 171058-21-2 | F6 | Possible genotoxicant | P < 0.0001 |
| 2-(2H-Benzotriazol-2-yl)-4-methylphenol | 2440-22-4 | B11 | Possible genotoxicant | P < 0.0001 |
| 1-Methyl-3-tetradecylimidazolium bis(trifluoromethylsulfonyl)imide | 404001-49-6 | F7 | Possible genotoxicant | P < 0.0001 |
| Bisphenol AF | 1478-61-1 | D6 | Possible genotoxicant | P < 0.0001 |
| p-(2,3-Epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline | 5026-74-4 | D3 | Possible genotoxicant | P < 0.0001 |
| 4-Aminoazobenzene | 60-09-3 | B10 | Possible genotoxicant | P < 0.0001 |
| 6-Azacytidine | 3131-60-0 | E12 | Possible genotoxicant | P < 0.05 |
| 3’-Methyl-4-dimethylaminoazobenzene | 55-80-1 | D12 | Possible genotoxicant | P < 0.05 |
| Cyclohexanone | 108-94-1 | C9 | Non-genotoxicant | P < 0.0001 |
| Melamine | 108-78-1 | E9 | Non-genotoxicant | P < 0.0001 |
| Progesterone | 57-83-0 | B3 | Non-genotoxicant | P < 0.0001 |
| Curcumin | 458-37-7 | A5 | Non-genotoxicant | P < 0.0001 |
| Di-(2-ethylhexyl)phthalate | 117-81-7 | B2 | Non-genotoxicant | P < 0.05 |
| Phthalic anhydride | 85-44-9 | E10 | Non-genotoxicant | P < 0.05 |