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. 2018 Feb 9;8:2779. doi: 10.1038/s41598-018-20941-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network of the change in cytokines with exercise. Vertex colors are dark blue for strongly negative average delta to dark red for strongly positive average delta. Degree of centrality of cytokines is represented by the diameter of its vertex. The diameter of a cytokine’s vertex is proportional to its quantity of direct direct connections (blue lines) with other cytokines. In (A) Controls: IL-5, TNF-alpha and IL-2 are richly connected while in (B) ME/CFS: CXCL10, VEGF and IL-15 are richly interconnected. IL-4 appeared to play a similar role in both networks.