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. 2018 Feb 5;5:16. doi: 10.3389/fmed.2018.00016

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Copyright © 2018 Tzounakas, Gevi, Georgatzakou, Zolla, Papassideri, Kriebardis, Rinalducci and Antonelou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hemolysis and extracellular vesicles (EV) analyses in fresh frozen plasma (FFP) units prepared from G6PD-deficient (G6PD⁻) and control donors. Free hemoglobin (Hb). (A) and EV-associated procoagulant activity (B) levels in the G6PD⁻ and control FFP units. (C) Enumeration and phenotyping of total and annexin V positive (AnnV⁺) EVs by flow cytometry. R-, P-, L-EVs stand for red cell-, platelet-, and leukocyte-derived EVs, respectively. *p < 0.05, G6PD⁻ vs. control FFPs; error bars: mean ± SD. (D) Representative immunoblots showing similar Hb levels (solid arrows) but variable expression of other protein components in EVs precipitated by high-speed centrifugation of equal volumes of G6PD⁻ and control FFP. Dashed arrow: oxidized Hb bands.