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. 2018 Feb 5;5:16. doi: 10.3389/fmed.2018.00016

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Copyright © 2018 Tzounakas, Gevi, Georgatzakou, Zolla, Papassideri, Kriebardis, Rinalducci and Antonelou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Important features identified by uni- and multivariate analyses. (A) G6PD⁻ vs. control variable importance in projection (VIP) plot; colored boxes on the right indicate the relative concentrations of the corresponding metabolite in each group under current study. (B) Volcano plot showing the distribution of the fold changes in metabolite concentrations. Metabolites with absolute fold change >2 and adjusted p-value (FDR < 0.05) are indicated in pink. Comparisons were analyzed using Student’s t-test.