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. 2018 Feb 5;5:16. doi: 10.3389/fmed.2018.00016

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Copyright © 2018 Tzounakas, Gevi, Georgatzakou, Zolla, Papassideri, Kriebardis, Rinalducci and Antonelou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network presentation of correlations among biochemical, physiological, and metabolomic variables in control FFP units. “Magnification” of a part of the total interactome of control fresh frozen plasma (FFP) units (networks in black circles) allowed focusing on the main connections between redox, EVs, and metabolic parameters. In the subnetwork of 266 connections (see Table S1 in Supplementary Material for code numbering and abbreviations), uric acid (UA), homocysteine, and reduced glutathione (GSH) constituted significant hub nodes, while ascorbic acid had correlations with the uric-acid-independent antioxidamt capacity of the FFP unit. Light blue dashed arrows indicate metabolites of high connectivity, and light blue circles stand for distinct groups of highly interconnected variables, or “boxes,” corresponding to FFP EVs and antioxidant capacity. Only the statistical significant correlations at p < 0.05 are shown. The length of each line is inversely proportional to the r value of the correlation (the shorter the edge, the higher the r value). Red lines: positive correlations; gray lines: negative correlations.