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. 2018 Feb 5;9:149. doi: 10.3389/fimmu.2018.00149

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Copyright © 2018 Cheng, Jing, Kang, Yang, Li, Yu, Peng, Li, Wei, Gong, Miron, Zhang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between Mst1 and T cell differentiation. (A) Mst1 promotes the activation of Foxp3 through antagonizing the activity of AKT and Sirt1, inducing the differentiation of regulatory T cell (Treg). (B) Combination of CD80 to CTLA-4 activates Mst1, which regulates the activity of Blimp1 and Bim puma, facilitating the terminal differentiation of CD8⁺ T cells. (C) Mst1^−/− CD4⁺ T cells are inclined to differentiate to T helper cells (Th)2, which induce B cell activation by producing interleukin (IL)-4. (D) Mst1^−/− dendritic cells secret more IL-6, which regulates Th17 differentiation by agonizing IL-6R of CD4⁺ T cells.