Figure 3.

Top immune predictors of chronic Heligmosomoides polygyrus worm burdens in wild wood mice. (A) Average ranking of immune gene transcripts based on Elastic Net coefficients of 50 models trained on 22 untreated wood mice from HW and CW (see Materials and Methods for details on immune gene selection procedure and model training). (B) Regression plots of the top five positive and negative clusters based on their coefficients against log-transformed H. polygyrus burdens, for which p ≤ 0.01. In regression plots, each point represents a wood mouse, the solid line is the regression line and the shaded areas represent the corresponding 95% bootstrapped confidence intervals.