Table 1.

Overview of AQP regulation during inflammation (↑ upregulation, ↓ downregulation, ? unknown regulation, = unaffected)

Aquaporin	Tissue	Regulation during inflammation	References
AQP1	Immune cells	↑ In leukocytes and cell lines (THP-1)	[8, 9]
	Heart	↑ In cardiac cells	[58]
	Lung	↓ In lung tissue after LPS	[5, 6]
AQP2	Kidney	↓ In renal tissue after LPS	[37]
AQP3	Immune cells	↓ In leukocytes of septic patients	[8]
AQP4	Brain	↑ In brain and anterior pituitary gland	[31, 75]
AQP5	Lung	↓ In lung tissue after LPS	[65]
	Immune cells	↓ In THP-1 cells after LPS	[9]
AQP7	Immune cells	? Mouse resident peritoneal macrophages	[76]
AQP8	Liver	↓ In hepatic cells	[11]
	Lung	= In bronchial epithelial cells	[61]
AQP9	Immune cells	↑ In neutrophils of SIRS patients	[12]
	Immune cells	? Mouse resident peritoneal macrophages	[76]
	Lung	= In bronchial epithelial cells	[61]