. 2018 Jan 16;9(2):103–108. doi: 10.1021/acsmedchemlett.7b00450

Table 3. DGAT1 Activities and Solubility of Racemates 12a and 12g and Their Corresponding Enantiomers (S-12a, R-12a, and S-12g, R-12g).

compd #	hDGAT1 CPM IC₅₀ (nM)^a	hDGAT1 LE IC₅₀ (nM)^a	rDGAT1 LE IC₅₀ (nM)^a	C2C12 Inh. at 300 nM (%)^a	solubility (μg/mL)^a
12a (Rac)	3	8	158	62	39
S-12a	2.5	1	126	75	78
R-12a	126	251	631	27	88
12g (Rac)	2	ND^b	ND^b	72	100
S-12g	2	8	158	83	5
R-12g	158	ND^b	1260	ND^b	0.4

Value is an average of at least n = 2.

ND = not determined.