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| species
(strain) |
|||
|---|---|---|---|
| parameter | mouse (C57BL/6J) | rat (Sprague–Dawley) | dog (Beagle) |
| dose IV/PO (mg/kg) | 2.2/2.7 | 1/2 | 1.8/5.3 |
| CLp (mL/min/kg) | 42.3 | 6.3 | 4.6 |
| VSS (L/kg) | 2.4 | 1.0 | 0.6 |
| IV T1/2 (h) | 2.6 | 3.9 | 4.6 |
| oral bioavailability (%F) | 54 | 87 | 149 |
