Table 2.
Clinico-laboratory findings of herpetic hepatitis in postsurgical and non-surgical immunocompetent patients
| Postsurgical patients (n = 15) | Non-surgical patients (n = 42) | P value | |
| Gender (M/F) (n) | 8/7 | 18/24 | 0.454 |
| Age (yr) | 58 (15-93) (n = 15) | 44 (15-87) (n = 43) | 0.060 |
| Clinical manifestation | |||
| (present/absent or ND) | |||
| Fever (n) | 14/1 | 42/0 | 0.263 |
| Nausea, vomiting, diarrhea (n) | 6/9 (17.5%) | 10/32 (23.8%) | 0.312 |
| Herpetic lesion present/none (n) | 3/8 (27.3%) | 20/19 (51.2%) | 0.308 |
| Transmission route | |||
| Identified or suspected (n) | 3 (20%) | 10 (23.8%) | 0.535 |
| Surgical wounds (Trans-genital tracts) (n = 2) | Sexually (n = 6) | ||
| Tran-esophagus (n = 1) | Percutaneous (n = 1) | ||
| Trans-esophagus (n = 2) | |||
| Trans-rectum (n = 1) | |||
| Leukocyte count (/mm3) | 3905 (900-10100) (n = 14) | 2600 (1000-7300) (n = 39) | 0.152 |
| AST (U/L) | 10,340 (5000-20692) (n = 10) | 5664 (92-18937) (n = 39) | 0.006 |
| ALT | 5116 (2970-7000) (n = 8) | 3248 (141-13980) (n = 29) | 0.048 |
| Total bilirubin (mg/dL) | 2.1 (2-8.5) (n = 6) | 4.4 (0.1-35) (n = 25) | 0.154 |
| Serology | |||
| positive/negative (n) | 2/3 (40%) | 14/12 (53.8%) | 0.654 |
| PCR analyzed (yes/no) (n) | 3/12 (20%) | 5/39 (8.4%) | 0.407 |
| HSV type (1/2/1 and 2) (n) | 5/3/0 | 14/14/3 | 1.0 |
| Ante-mortem diagnosis | |||
| yes/no (n) | 3/12 (20%) | 24/18 (57.1%) | 0.017 |
| ACV treatment | |||
| Yes/ no (n) | 3/12 (20%) | 21 / 21 (50%) | 0.041 |
| Liver transplantation | |||
| Yes/no (n) | 2/13 | 6/38 | 1.0 |
| Outcome | |||
| Survived/ died (overall) (n) | 2/13 (13.3%) | 12/30 (28.6%) | 0.312 |
| Survival time12 (d) | 13 (6-30) (n = 12) | 10 (5-29) (n = 26) | 0.729 |
| Survival time2 after liver dysfunction emerged (d) | 5.5 (1-9) (n = 11) | 5 (1-16)) (n = 18) | 0.821 |
Continuous data were presented as median with range from minimum and maximum values. For categorical variables and continuous measures, differences were compared using Fisher’s exact test or χ2 test, and the Mann-Whitney U test, respectively.
1
Survival time: were expressed as the days after surgery or symptoms emerging;
2
Survival time: Data were excluded from the surviving patients. ACV: Acyclovir; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; HSV: Herpes simplex virus; LT: Liver transplantation; PCR: Polymerase chain reaction.