Figure 1.

Schematic representation of the synaptic vesicle (SV) dynamics at the presynaptic terminal. SVs that accumulate at the presynaptic terminal originate from various sources: they are either actively transported to the synapses or recycled locally, either in the close proximity to the active zone (periactive zone) or budding from endosome-like structures. Furthermore, significant exchange of SVs happens between adjacent synapses. Active zone is depicted in dark yellow, SVs in orange, clathrin coated vesicles (CCVs) in dark brown and endosome-like structure in light-brown color.