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. 2018 Feb 6;9:124. doi: 10.3389/fmicb.2018.00124

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Copyright © 2018 Deng, Sztajer, Jarek, Bhuju and Wagner-Döbler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic interaction model showing synergistic pathogenicity of F. nucleatum, P. gingivalis, and T. denticola based on their transcriptional profiles in chronic periodontitis. Blue triangles denote down-regulation, red triangles up-regulation in vivo, the number in parentheses indicate the number of genes of this particular function, and the red circle denotes a set of genes which are highly expressed both in vivo and in laboratory culture. The dashed line indicates contribution of free amino acids by other members of the periodontal microbiota.